Anti-Inflammatory Effects Induced by a Polyphenolic Granular Complex from Olive (<i>Olea europaea</i>, Mainly <i>Cultivar coratina</i>): Results from In Vivo and Ex Vivo Studies in a Model of Inflammation and MIA-Induced Osteoarthritis
MOMAST<sup>®</sup> GR25 is a polyphenolic granular complex from olive pressing juice with high total content in polyphenols. In this work, we evaluated the possible anti-inflammatory effects of MOMAST<sup>®</sup> GR25 in both acute and chronic inflammatory models. MOMAST<s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/7/1487 |
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| author | Lucia Recinella Laura Micheli Annalisa Chiavaroli Maria Loreta Libero Giustino Orlando Luigi Menghini Alessandra Acquaviva Simonetta Di Simone Claudio Ferrante Carla Ghelardini Luigi Brunetti Sheila Leone |
| author_facet | Lucia Recinella Laura Micheli Annalisa Chiavaroli Maria Loreta Libero Giustino Orlando Luigi Menghini Alessandra Acquaviva Simonetta Di Simone Claudio Ferrante Carla Ghelardini Luigi Brunetti Sheila Leone |
| author_sort | Lucia Recinella |
| collection | DOAJ |
| description | MOMAST<sup>®</sup> GR25 is a polyphenolic granular complex from olive pressing juice with high total content in polyphenols. In this work, we evaluated the possible anti-inflammatory effects of MOMAST<sup>®</sup> GR25 in both acute and chronic inflammatory models. MOMAST<sup>®</sup> GR25 decreased the levels of prostaglandin (PG) E<sub>2</sub> and 8-iso-PGF<sub>2α</sub> in isolated rat colon, liver, and heart specimens stimulated with lipopolysaccharide (LPS). In vivo, compared to controls, rats treated with MOMAST<sup>®</sup> GR25 (100 mg/kg to 1 g/kg) showed a significant reduction in both licking/biting time in the formalin test. In a rat model of osteoarthritis by monoiodoacetate (MIA) injection, MOMAST<sup>®</sup> GR25 showed pain-relieving properties when acutely administered, reducing mechanical hyperalgesia and spontaneous pain. Moreover, a repeated daily treatment with MOMAST<sup>®</sup> GR25 (300 mg/kg) fully counteracted osteoarticular pain without the development of tolerance to the antinociceptive effect. Taken together, our present findings showed that MOMAST<sup>®</sup> GR25 could represent a potential strategy for the treatment of inflammation and pain. |
| first_indexed | 2024-03-09T11:32:46Z |
| format | Article |
| id | doaj.art-9684d30d21e74e24b45716325afaef08 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T11:32:46Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-9684d30d21e74e24b45716325afaef082023-11-30T23:48:57ZengMDPI AGNutrients2072-66432022-04-01147148710.3390/nu14071487Anti-Inflammatory Effects Induced by a Polyphenolic Granular Complex from Olive (<i>Olea europaea</i>, Mainly <i>Cultivar coratina</i>): Results from In Vivo and Ex Vivo Studies in a Model of Inflammation and MIA-Induced OsteoarthritisLucia Recinella0Laura Micheli1Annalisa Chiavaroli2Maria Loreta Libero3Giustino Orlando4Luigi Menghini5Alessandra Acquaviva6Simonetta Di Simone7Claudio Ferrante8Carla Ghelardini9Luigi Brunetti10Sheila Leone11Department of Pharmacy, “G. d’Annunzio” University, 66013 Chieti, ItalyDepartment of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, 50139 Florence, ItalyDepartment of Pharmacy, “G. d’Annunzio” University, 66013 Chieti, ItalyDepartment of Pharmacy, “G. d’Annunzio” University, 66013 Chieti, ItalyDepartment of Pharmacy, “G. d’Annunzio” University, 66013 Chieti, ItalyDepartment of Pharmacy, “G. d’Annunzio” University, 66013 Chieti, ItalyDepartment of Pharmacy, “G. d’Annunzio” University, 66013 Chieti, ItalyDepartment of Pharmacy, “G. d’Annunzio” University, 66013 Chieti, ItalyDepartment of Pharmacy, “G. d’Annunzio” University, 66013 Chieti, ItalyDepartment of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, 50139 Florence, ItalyDepartment of Pharmacy, “G. d’Annunzio” University, 66013 Chieti, ItalyDepartment of Pharmacy, “G. d’Annunzio” University, 66013 Chieti, ItalyMOMAST<sup>®</sup> GR25 is a polyphenolic granular complex from olive pressing juice with high total content in polyphenols. In this work, we evaluated the possible anti-inflammatory effects of MOMAST<sup>®</sup> GR25 in both acute and chronic inflammatory models. MOMAST<sup>®</sup> GR25 decreased the levels of prostaglandin (PG) E<sub>2</sub> and 8-iso-PGF<sub>2α</sub> in isolated rat colon, liver, and heart specimens stimulated with lipopolysaccharide (LPS). In vivo, compared to controls, rats treated with MOMAST<sup>®</sup> GR25 (100 mg/kg to 1 g/kg) showed a significant reduction in both licking/biting time in the formalin test. In a rat model of osteoarthritis by monoiodoacetate (MIA) injection, MOMAST<sup>®</sup> GR25 showed pain-relieving properties when acutely administered, reducing mechanical hyperalgesia and spontaneous pain. Moreover, a repeated daily treatment with MOMAST<sup>®</sup> GR25 (300 mg/kg) fully counteracted osteoarticular pain without the development of tolerance to the antinociceptive effect. Taken together, our present findings showed that MOMAST<sup>®</sup> GR25 could represent a potential strategy for the treatment of inflammation and pain.https://www.mdpi.com/2072-6643/14/7/1487<i>Cultivar coratina</i>inflammationosteoarthritishydroxytyrosolpain |
| spellingShingle | Lucia Recinella Laura Micheli Annalisa Chiavaroli Maria Loreta Libero Giustino Orlando Luigi Menghini Alessandra Acquaviva Simonetta Di Simone Claudio Ferrante Carla Ghelardini Luigi Brunetti Sheila Leone Anti-Inflammatory Effects Induced by a Polyphenolic Granular Complex from Olive (<i>Olea europaea</i>, Mainly <i>Cultivar coratina</i>): Results from In Vivo and Ex Vivo Studies in a Model of Inflammation and MIA-Induced Osteoarthritis Nutrients <i>Cultivar coratina</i> inflammation osteoarthritis hydroxytyrosol pain |
| title | Anti-Inflammatory Effects Induced by a Polyphenolic Granular Complex from Olive (<i>Olea europaea</i>, Mainly <i>Cultivar coratina</i>): Results from In Vivo and Ex Vivo Studies in a Model of Inflammation and MIA-Induced Osteoarthritis |
| title_full | Anti-Inflammatory Effects Induced by a Polyphenolic Granular Complex from Olive (<i>Olea europaea</i>, Mainly <i>Cultivar coratina</i>): Results from In Vivo and Ex Vivo Studies in a Model of Inflammation and MIA-Induced Osteoarthritis |
| title_fullStr | Anti-Inflammatory Effects Induced by a Polyphenolic Granular Complex from Olive (<i>Olea europaea</i>, Mainly <i>Cultivar coratina</i>): Results from In Vivo and Ex Vivo Studies in a Model of Inflammation and MIA-Induced Osteoarthritis |
| title_full_unstemmed | Anti-Inflammatory Effects Induced by a Polyphenolic Granular Complex from Olive (<i>Olea europaea</i>, Mainly <i>Cultivar coratina</i>): Results from In Vivo and Ex Vivo Studies in a Model of Inflammation and MIA-Induced Osteoarthritis |
| title_short | Anti-Inflammatory Effects Induced by a Polyphenolic Granular Complex from Olive (<i>Olea europaea</i>, Mainly <i>Cultivar coratina</i>): Results from In Vivo and Ex Vivo Studies in a Model of Inflammation and MIA-Induced Osteoarthritis |
| title_sort | anti inflammatory effects induced by a polyphenolic granular complex from olive i olea europaea i mainly i cultivar coratina i results from in vivo and ex vivo studies in a model of inflammation and mia induced osteoarthritis |
| topic | <i>Cultivar coratina</i> inflammation osteoarthritis hydroxytyrosol pain |
| url | https://www.mdpi.com/2072-6643/14/7/1487 |
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