Aldosterone Negatively Regulates Nrf2 Activity: An Additional Mechanism Contributing to Oxidative Stress and Vascular Dysfunction by Aldosterone

Aldosterone Negatively Regulates Nrf2 Activity: An Additional Mechanism Contributing to Oxidative Stress and Vascular Dysfunction by Aldosterone

High levels of aldosterone (Aldo) trigger oxidative stress and vascular dysfunction independent of effects on blood pressure. We sought to determine whether Aldo disrupts Nrf2 signaling, the main transcriptional factor involved in antioxidant responses that aggravate cell injury. Thoracic aorta from...

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Bibliographic Details
Main Authors: Daniel Rodrigues, Tiago J. Costa, Josiane F. Silva, José Teles de Oliveira Neto, Juliano V. Alves, Aline G. Fedoce, Rafael Menezes Costa, Rita C. Tostes
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
aldosterone
vascular dysfunction
oxidative stress
Nrf2
Online Access:https://www.mdpi.com/1422-0067/22/11/6154

Internet

https://www.mdpi.com/1422-0067/22/11/6154

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