Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity

Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity

Summary: Parkinson’s disease-causing leucine-rich repeat kinase 2 (LRRK2) mutations lead to varying degrees of Rab GTPase hyperphosphorylation. Puzzlingly, LRRK2 GTPase-inactivating mutations—which do not affect intrinsic kinase activity—lead to higher levels of cellular Rab phosphorylation than kin...

Full description

Bibliographic Details
Main Authors: Capria Rinaldi, Christopher S. Waters, Zizheng Li, Karl Kumbier, Lee Rao, R. Jeremy Nichols, Matthew P. Jacobson, Lani F. Wu, Steven J. Altschuler
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Cell Reports
Subjects:
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723004588

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723004588

Similar Items