Reversal of cholestatic liver disease by the inhibition of sphingosine 1-phosphate receptor 2 signaling

Aims The objective of this study is to examine the impact of inhibiting Sphingosine 1-phosphate receptor 2 (S1PR2) on liver inflammation, fibrogenesis, and changes of gut microbiome in the context of cholestasis-induced conditions. Methods The cholestatic liver injury model was developed by common b...

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Bibliographic Details
Main Authors: Huiling Cao, Lin Chen, Ziyang Zeng, Xianfeng Wu, Yuhao Lei, Wen Jia, Guang Yue, Bin Yi, Yu-jie Li, Yuan Shi
Format: Article
Language:English
Published: PeerJ Inc. 2024-01-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/16744.pdf