Rh(II)-mediated domino [4 + 1]-annulation of α-cyanothioacetamides using diazoesters: A new entry for the synthesis of multisubstituted thiophenes

Rh(II)-mediated domino [4 + 1]-annulation of α-cyanothioacetamides using diazoesters: A new entry for the synthesis of multisubstituted thiophenes

A new approach towards the synthesis of multisubstituted thiophenes is elaborated based on Rh(II)-catalyzed domino reactions of acyclic diazoesters with α-cyanothioacetamides. It provides a way for the preparation of 5-amino-3-(alkoxycarbonylamino)thiophene-2-carboxylates, 2-(5-amino-2-methoxycarbon...

Full description

Bibliographic Details
Main Authors: Jury J. Medvedev, Ilya V. Efimov, Yuri M. Shafran, Vitaliy V. Suslonov, Vasiliy A. Bakulev, Valerij A. Nikolaev
Format: Article
Language:English
Published: Beilstein-Institut 2017-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
[4 + 1]-annulation
catalysis
diazo compounds
domino reactions
thiophenes
Online Access:https://doi.org/10.3762/bjoc.13.253

Internet

https://doi.org/10.3762/bjoc.13.253

Similar Items