Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model

Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model

A relatively low clearance is one of the prominent favorable features of immunoglobulin G1-based therapeutic monoclonal antibodies (mAbs). Various studies have observed differential clearance of mAb glycoforms, including oligomannose glycoforms, which are considered a critical quality attribute beca...

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Bibliographic Details
Main Authors: David Falck, Martin Lechmann, Ana Momčilović, Marco Thomann, Carolien A. M. Koeleman, Cordula Jany, Sebastian Malik, Manfred Wuhrer, Dietmar Reusch
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:mAbs
Subjects:
Pharmacokinetics
N-glycosylation
monoclonal antibodies
liquid chromatography – mass spectrometry
glycoengineering
minipig
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2022.2145929

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2022.2145929

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