Repositioning of Quinazolinedione-Based Compounds on Soluble Epoxide Hydrolase (sEH) through 3D Structure-Based Pharmacophore Model-Driven Investigation

Repositioning of Quinazolinedione-Based Compounds on Soluble Epoxide Hydrolase (sEH) through 3D Structure-Based Pharmacophore Model-Driven Investigation

The development of new bioactive compounds represents one of the main purposes of the drug discovery process. Various tools can be employed to identify new drug candidates against pharmacologically relevant biological targets, and the search for new approaches and methodologies often represents a cr...

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Bibliographic Details
Main Authors: Erica Gazzillo, Stefania Terracciano, Dafne Ruggiero, Marianna Potenza, Maria Giovanna Chini, Gianluigi Lauro, Katrin Fischer, Robert Klaus Hofstetter, Assunta Giordano, Oliver Werz, Ines Bruno, Giuseppe Bifulco
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
drug repositioning
soluble epoxide hydrolase
drug discovery
computational techniques
chemical synthesis
anti-inflammatory agents
Online Access:https://www.mdpi.com/1420-3049/27/12/3866

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https://www.mdpi.com/1420-3049/27/12/3866

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