Design and comparative in-vitro and in-vivo evaluation of starch-acrylate graft copolymer based salbutamol sulphate sustained release tablets
The present work deals with the development of controlled release tablets of salbutamol sulphate (SS) using graft copolymers of methyl methacrylate (St-g-PMMA and Ast-g-PMMA) on starch and acetylated starch. Formulations were evaluated for physical characteristics like hardness, friability, drug rel...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-06-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087614001007 |
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| author | Pankaj Kumar Ashok Laxmanrao Ganure Bharat Bhushan Subudhi Shubhanjali Shukla Pooja Upadhyay |
| author_facet | Pankaj Kumar Ashok Laxmanrao Ganure Bharat Bhushan Subudhi Shubhanjali Shukla Pooja Upadhyay |
| author_sort | Pankaj Kumar |
| collection | DOAJ |
| description | The present work deals with the development of controlled release tablets of salbutamol sulphate (SS) using graft copolymers of methyl methacrylate (St-g-PMMA and Ast-g-PMMA) on starch and acetylated starch. Formulations were evaluated for physical characteristics like hardness, friability, drug release, drug content and weight variations, which fulfilled all the official requirements of tablet dosage form. The release rates from formulated matrix tablets were studied at SGF (pH 1.2) followed by SIF (pH 6.8). Drug release from the graft copolymer based tablets was found to be sustained upto the 14 h with >75% drug release. The in-vitro release study showed that the graft copolymer based matrix formulations (F3 & F4) exhibited highest correlation value (r2) for higuchi kinetic model and Korsmeyer's model with n values between 0.61 and 0.67 proved that release mechanisms were governed by both diffusion and erosion mechanism. There was no significant difference in the pharmacokinetic parameters (tmax, Cmax, AUC, Ke, and t1/2) of the graft copolymers matrices and HPMC K100M matrix tablets, indicating their comparable sustained release effect. The potential of graft copolymers to sustain the drug release is well supported by in-vivo pharmacokinetic studies and their adequate physicochemical properties make them promising excipients for controlled drug delivery system. |
| first_indexed | 2024-12-16T17:46:08Z |
| format | Article |
| id | doaj.art-96919c21c7c1433291dac4ac97f9cb16 |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-12-16T17:46:08Z |
| publishDate | 2015-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-96919c21c7c1433291dac4ac97f9cb162022-12-21T22:22:27ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762015-06-0110323924610.1016/j.ajps.2014.12.003Design and comparative in-vitro and in-vivo evaluation of starch-acrylate graft copolymer based salbutamol sulphate sustained release tabletsPankaj Kumar0Ashok Laxmanrao Ganure1Bharat Bhushan Subudhi2Shubhanjali Shukla3Pooja Upadhyay4School of Pharmaceutical Sciences, Siksha O Anusandhan University, Khandagiri Square, Bhubaneswar, Orissa 751030, IndiaSahyadri College of Pharmacy, Sangola, Solapur, M.S. 413307, IndiaSchool of Pharmaceutical Sciences, Siksha O Anusandhan University, Khandagiri Square, Bhubaneswar, Orissa 751030, IndiaDepartment of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, IndiaDepartment of Advanced Pharmaceutical Science, Manipal University, Karnataka 576104, IndiaThe present work deals with the development of controlled release tablets of salbutamol sulphate (SS) using graft copolymers of methyl methacrylate (St-g-PMMA and Ast-g-PMMA) on starch and acetylated starch. Formulations were evaluated for physical characteristics like hardness, friability, drug release, drug content and weight variations, which fulfilled all the official requirements of tablet dosage form. The release rates from formulated matrix tablets were studied at SGF (pH 1.2) followed by SIF (pH 6.8). Drug release from the graft copolymer based tablets was found to be sustained upto the 14 h with >75% drug release. The in-vitro release study showed that the graft copolymer based matrix formulations (F3 & F4) exhibited highest correlation value (r2) for higuchi kinetic model and Korsmeyer's model with n values between 0.61 and 0.67 proved that release mechanisms were governed by both diffusion and erosion mechanism. There was no significant difference in the pharmacokinetic parameters (tmax, Cmax, AUC, Ke, and t1/2) of the graft copolymers matrices and HPMC K100M matrix tablets, indicating their comparable sustained release effect. The potential of graft copolymers to sustain the drug release is well supported by in-vivo pharmacokinetic studies and their adequate physicochemical properties make them promising excipients for controlled drug delivery system.http://www.sciencedirect.com/science/article/pii/S1818087614001007Salbutamol sulphateMethyl methacrylateGraft copolymersAcetylated starchKorsmeyer's modelIn vitro and in vivo |
| spellingShingle | Pankaj Kumar Ashok Laxmanrao Ganure Bharat Bhushan Subudhi Shubhanjali Shukla Pooja Upadhyay Design and comparative in-vitro and in-vivo evaluation of starch-acrylate graft copolymer based salbutamol sulphate sustained release tablets Asian Journal of Pharmaceutical Sciences Salbutamol sulphate Methyl methacrylate Graft copolymers Acetylated starch Korsmeyer's model In vitro and in vivo |
| title | Design and comparative in-vitro and in-vivo evaluation of starch-acrylate graft copolymer based salbutamol sulphate sustained release tablets |
| title_full | Design and comparative in-vitro and in-vivo evaluation of starch-acrylate graft copolymer based salbutamol sulphate sustained release tablets |
| title_fullStr | Design and comparative in-vitro and in-vivo evaluation of starch-acrylate graft copolymer based salbutamol sulphate sustained release tablets |
| title_full_unstemmed | Design and comparative in-vitro and in-vivo evaluation of starch-acrylate graft copolymer based salbutamol sulphate sustained release tablets |
| title_short | Design and comparative in-vitro and in-vivo evaluation of starch-acrylate graft copolymer based salbutamol sulphate sustained release tablets |
| title_sort | design and comparative in vitro and in vivo evaluation of starch acrylate graft copolymer based salbutamol sulphate sustained release tablets |
| topic | Salbutamol sulphate Methyl methacrylate Graft copolymers Acetylated starch Korsmeyer's model In vitro and in vivo |
| url | http://www.sciencedirect.com/science/article/pii/S1818087614001007 |
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