Translatability of preclinical to early clinical tolerable and pharmacologically active dose ranges for central nervous system active drugs

Translatability of preclinical to early clinical tolerable and pharmacologically active dose ranges for central nervous system active drugs

Abstract The primary purpose of this study was to assess the translatability of preclinical to early clinical tolerable and pharmacologically active dose ranges for central nervous system (CNS) active drugs. As a part of this, IBs were reviewed on reporting quality. Investigator’s Brochures (IBs) of...

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Main Authors: Guilherme S. Ferreira, Francis M. Dijkstra, Désirée H. Veening-Griffioen, Wouter P. C. Boon, Huub Schellekens, Ellen H. M. Moors, Peter J. K. van Meer, Frederik E. Stuurman, Joop M. A. van Gerven
Format: Article
Language:English
Published: Nature Publishing Group 2023-03-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02353-1

Internet

https://doi.org/10.1038/s41398-023-02353-1

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