Translatability of preclinical to early clinical tolerable and pharmacologically active dose ranges for central nervous system active drugs
Abstract The primary purpose of this study was to assess the translatability of preclinical to early clinical tolerable and pharmacologically active dose ranges for central nervous system (CNS) active drugs. As a part of this, IBs were reviewed on reporting quality. Investigator’s Brochures (IBs) of...
Main Authors: | Guilherme S. Ferreira, Francis M. Dijkstra, Désirée H. Veening-Griffioen, Wouter P. C. Boon, Huub Schellekens, Ellen H. M. Moors, Peter J. K. van Meer, Frederik E. Stuurman, Joop M. A. van Gerven |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2023-03-01
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Series: | Translational Psychiatry |
Online Access: | https://doi.org/10.1038/s41398-023-02353-1 |
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