Downregulation of the Cl-/HCO3-Exchanger Pendrin in Kidneys of Mice with Cystic Fibrosis: Role in the Pathogenesis of Metabolic Alkalosis

Downregulation of the Cl-/HCO3-Exchanger Pendrin in Kidneys of Mice with Cystic Fibrosis: Role in the Pathogenesis of Metabolic Alkalosis

Background/Aims: Patients with cystic fibrosis (CF) are prone to the development of metabolic alkalosis; however, the pathogenesis of this life threatening derangement remains unknown. We hypothesized that altered acid base transport machinery in the kidney collecting duct underlies the mechanism of...

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Bibliographic Details
Main Authors: Mujan Varasteh Kia, Sharon Barone, Alicia A. McDonough, Kamyar Zahedi, Jie Xu, Manoocher Soleimani
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
Metabolic Alkalosis
Cystic Fibrosis
Pendrin
CFTR
Online Access:https://www.karger.com/Article/FullText/487691

Internet

https://www.karger.com/Article/FullText/487691

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