Allopurinol Disrupts Purine Metabolism to Increase Damage in Experimental Colitis

Allopurinol Disrupts Purine Metabolism to Increase Damage in Experimental Colitis

Inflammatory bowel disease (IBD) is marked by a state of chronic energy deficiency that limits gut tissue wound healing. This energy shortfall is partially due to microbiota dysbiosis, resulting in the loss of microbiota-derived metabolites, which the epithelium relies on for energy procurement. The...

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Bibliographic Details
Main Authors: Corey S. Worledge, Rachael E. Kostelecky, Liheng Zhou, Geetha Bhagavatula, Sean P. Colgan, J. Scott Lee
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cells
Subjects:
allopurinol
purines
energy metabolism
wound healing
proliferation
inflammatory bowel disease
Online Access:https://www.mdpi.com/2073-4409/13/5/373

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https://www.mdpi.com/2073-4409/13/5/373

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