The mechanism of MICU-dependent gating of the mitochondrial Ca2+uniporter

The mechanism of MICU-dependent gating of the mitochondrial Ca2+uniporter

Ca2+ entry into mitochondria is through the mitochondrial calcium uniporter complex (MCUcx), a Ca2+-selective channel composed of five subunit types. Two MCUcx subunits (MCU and EMRE) span the inner mitochondrial membrane, while three Ca2+-regulatory subunits (MICU1, MICU2, and MICU3) reside in the...

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Bibliographic Details
Main Authors: Vivek Garg, Junji Suzuki, Ishan Paranjpe, Tiffany Unsulangi, Liron Boyman, Lorin S Milescu, W Jonathan Lederer, Yuriy Kirichok
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
mouse embryonic fibroblasts
mitochondrial calcium uniporter
mitochondria
ion channels
patch clamp
calcium signaling
Online Access:https://elifesciences.org/articles/69312

Internet

https://elifesciences.org/articles/69312

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