Stable expression of a truncated TLX variant drives differentiation of induced pluripotent stem cells into self-renewing neural stem cells for production of extracellular vesicles

Stable expression of a truncated TLX variant drives differentiation of induced pluripotent stem cells into self-renewing neural stem cells for production of extracellular vesicles

Abstract Background Neural stem cells (NSCs)-derived extracellular vesicles (EVs) possess great potential in treating severe neurological and cerebrovascular diseases, as they carry the modulatory and regenerative ingredients of NSCs. Induced pluripotent stem cells (iPSCs)-derived NSCs culture repre...

Full description

Bibliographic Details
Main Authors: Mingzhi Xu, Gang Chen, Yanan Dong, Shensi Xiang, Miaomiao Xue, Yongxue Liu, Haijing Song, Haifeng Song, Yi Wang
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Stem Cell Research & Therapy
Subjects:
TLX
Induced pluripotent stem cells
Neural stem cells
Long-term culture
Extracellular vesicles
Online Access:https://doi.org/10.1186/s13287-022-03131-4

Internet

https://doi.org/10.1186/s13287-022-03131-4

Similar Items