Emergence of daptomycin resistance in daptomycin-naïve rabbits with methicillin-resistant Staphylococcus aureus prosthetic joint infection is associated with resistance to host defense cationic peptides and mprF polymorphisms.

Emergence of daptomycin resistance in daptomycin-naïve rabbits with methicillin-resistant Staphylococcus aureus prosthetic joint infection is associated with resistance to host defense cationic peptides and mprF polymorphisms.

Previous studies of both clinically-derived and in vitro passage-derived daptomycin-resistant (DAP-R) Staphylococcus aureus strains demonstrated the coincident emergence of increased DAP MICs and resistance to host defense cationic peptides (HDP-R).In the present investigation, we studied a parental...

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Bibliographic Details
Main Authors: Nagendra N Mishra, Soo-Jin Yang, Liang Chen, Claudette Muller, Azzam Saleh-Mghir, Sebastian Kuhn, Andreas Peschel, Michael R Yeaman, Cynthia C Nast, Barry N Kreiswirth, Anne-Claude Crémieux, Arnold S Bayer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3747195?pdf=render

Internet

http://europepmc.org/articles/PMC3747195?pdf=render

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