The Preventive Effect of Dietary Antioxidants on Cervical Cancer Development
Cervical cancer results from a continuous process, starting from a normal cervical epithelium after human papillomavirus (HPV) infection and progressing to cervical intraepithelial neoplasia (CIN), before finally developing into invasive squamous carcinoma (ISC). In recent decades, dietary antioxida...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/56/11/604 |
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| author | Ayumi Ono Masafumi Koshiyama Miwa Nakagawa Yumiko Watanabe Eri Ikuta Keiko Seki Makiko Oowaki |
| author_facet | Ayumi Ono Masafumi Koshiyama Miwa Nakagawa Yumiko Watanabe Eri Ikuta Keiko Seki Makiko Oowaki |
| author_sort | Ayumi Ono |
| collection | DOAJ |
| description | Cervical cancer results from a continuous process, starting from a normal cervical epithelium after human papillomavirus (HPV) infection and progressing to cervical intraepithelial neoplasia (CIN), before finally developing into invasive squamous carcinoma (ISC). In recent decades, dietary antioxidants, such as vitamins, have received much attention in relation to cancer prevention. We reviewed the relevant literature to investigate the dietary and nutrient intake on cervical cancer. The intake of vitamins A and D and carotenoids may inhibit early cervical cancer development. The intake of folate may prevent or inhibit HPV infection rom progressing to various grades of CIN. The intake of vitamins C and E may widely inhibit the process of cervical cancer development. Polyphenols are often used in cases of cervical cancer in combination chemotherapy and radiation therapy. Regarding nutrients, different antioxidants may have differing abilities to intervene in the natural history of cervical diseases associated with HPV infection. Regarding foods, the intake of both vegetables and fruits containing multiple vitamins may widely suppress cervical cancer development. Most previous papers have described epidemiological studies. Thus, further research using in vitro and in vivo approaches will be needed to clarify the effects of the dietary and nutrient intake in detail. |
| first_indexed | 2024-03-12T11:15:50Z |
| format | Article |
| id | doaj.art-969ef0c90e774eb683837e829a33e075 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T11:15:50Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-969ef0c90e774eb683837e829a33e0752023-09-02T02:01:21ZengMDPI AGMedicina1010-660X2020-11-015660460410.3390/medicina56110604The Preventive Effect of Dietary Antioxidants on Cervical Cancer DevelopmentAyumi Ono0Masafumi Koshiyama1Miwa Nakagawa2Yumiko Watanabe3Eri Ikuta4Keiko Seki5Makiko Oowaki6Graduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, JapanDepartment of Women’s Health, Graduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, JapanGraduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, JapanDepartment of Women’s Health, Graduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, JapanGraduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, JapanGraduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, JapanGraduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, JapanCervical cancer results from a continuous process, starting from a normal cervical epithelium after human papillomavirus (HPV) infection and progressing to cervical intraepithelial neoplasia (CIN), before finally developing into invasive squamous carcinoma (ISC). In recent decades, dietary antioxidants, such as vitamins, have received much attention in relation to cancer prevention. We reviewed the relevant literature to investigate the dietary and nutrient intake on cervical cancer. The intake of vitamins A and D and carotenoids may inhibit early cervical cancer development. The intake of folate may prevent or inhibit HPV infection rom progressing to various grades of CIN. The intake of vitamins C and E may widely inhibit the process of cervical cancer development. Polyphenols are often used in cases of cervical cancer in combination chemotherapy and radiation therapy. Regarding nutrients, different antioxidants may have differing abilities to intervene in the natural history of cervical diseases associated with HPV infection. Regarding foods, the intake of both vegetables and fruits containing multiple vitamins may widely suppress cervical cancer development. Most previous papers have described epidemiological studies. Thus, further research using in vitro and in vivo approaches will be needed to clarify the effects of the dietary and nutrient intake in detail.https://www.mdpi.com/1010-660X/56/11/604dietary oxidantHPVcervical dysplasiacervical cancer |
| spellingShingle | Ayumi Ono Masafumi Koshiyama Miwa Nakagawa Yumiko Watanabe Eri Ikuta Keiko Seki Makiko Oowaki The Preventive Effect of Dietary Antioxidants on Cervical Cancer Development Medicina dietary oxidant HPV cervical dysplasia cervical cancer |
| title | The Preventive Effect of Dietary Antioxidants on Cervical Cancer Development |
| title_full | The Preventive Effect of Dietary Antioxidants on Cervical Cancer Development |
| title_fullStr | The Preventive Effect of Dietary Antioxidants on Cervical Cancer Development |
| title_full_unstemmed | The Preventive Effect of Dietary Antioxidants on Cervical Cancer Development |
| title_short | The Preventive Effect of Dietary Antioxidants on Cervical Cancer Development |
| title_sort | preventive effect of dietary antioxidants on cervical cancer development |
| topic | dietary oxidant HPV cervical dysplasia cervical cancer |
| url | https://www.mdpi.com/1010-660X/56/11/604 |
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