Synthesis and Biological Evaluation of Some New 3-Aryl-2-thioxo-2,3-dihydroquinazolin-4(1<i>H</i>)-ones and 3-Aryl-2-(benzylthio)quinazolin-4(3<i>H</i>)-ones as Antioxidants; COX-2, LDHA, α-Glucosidase and α-Amylase Inhibitors; and Anti-Colon Carcinoma and Apoptosis-Inducing Agents

Synthesis and Biological Evaluation of Some New 3-Aryl-2-thioxo-2,3-dihydroquinazolin-4(1<i>H</i>)-ones and 3-Aryl-2-(benzylthio)quinazolin-4(3<i>H</i>)-ones as Antioxidants; COX-2, LDHA, α-Glucosidase and α-Amylase Inhibitors; and Anti-Colon Carcinoma and Apoptosis-Inducing Agents

Oxidative stress, COX-2, LDHA and hyperglycemia are interlinked contributing pathways in the etiology, progression and metastasis of colon cancer. Additionally, dysregulated apoptosis in cells with genetic alternations leads to their progression in malignant transformation. Therefore, quinazolinones...

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Bibliographic Details
Main Authors: Nahed Nasser Eid El-Sayed, Taghreed M. Al-Otaibi, Assem Barakat, Zainab M. Almarhoon, Mohd. Zaheen Hassan, Maha I. Al-Zaben, Najeh Krayem, Vijay H. Masand, Abir Ben Bacha
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Pharmaceuticals
Subjects:
colorectal cancer
oxidative stress
inflammation
COX-2
Warburg effect
LDHA
Online Access:https://www.mdpi.com/1424-8247/16/10/1392

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https://www.mdpi.com/1424-8247/16/10/1392

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