Comparison of drug release and mechanical properties of tramadol-hydrochloride matrix tablets prepared with selected hydrophilic polymers
This study investigates using of high molecular weight hydrophilic polymers, hypromellose and hydroxypropylcellulose, for the preparation of sustained release matrix tablets containing high dose, highly soluble drug, tramadol HCl. Proportion of polymer, type of insoluble filler, proportion...
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| Format: | Article |
| Language: | English |
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Association of the Chemical Engineers of Serbia
2015-01-01
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| Series: | Chemical Industry and Chemical Engineering Quarterly |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/1451-9372/2015/1451-93721400040N.pdf |
| _version_ | 1818350793782198272 |
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| author | Nikolić Nenad D. Medarević Đorđe P. Đuriš Jelena D. Vasiljević Dragana D. |
| author_facet | Nikolić Nenad D. Medarević Đorđe P. Đuriš Jelena D. Vasiljević Dragana D. |
| author_sort | Nikolić Nenad D. |
| collection | DOAJ |
| description | This study investigates using of high molecular weight hydrophilic polymers,
hypromellose and hydroxypropylcellulose, for the preparation of sustained
release matrix tablets containing high dose, highly soluble drug, tramadol
HCl. Proportion of polymer, type of insoluble filler, proportion of tramadol
HCl, amount of drug in the tablet and compression pressure were recognized as
critical formulation and process parameters and their influence on drug
release and tablet mechanical properties was evaluated. Tensile strength was
used as indicator of mechanical properties of the tablets. Experiments were
performed with utilization of compaction simulator as a device which
simulates compaction profiles of large scale rotary tablet presses. In
formulations with both polymers proportion of tramadol HCl was the most
critical formulation parameter wherein increasing of the tramadol HCl
proportion increased its release rate in early stages of drug release.
Regarding the tablet mechanical characteristics, the influence of the filler
type has the most pronounced effect in formulations with both polymers.
Higher tensile strengths were obtained with Avicel PH 102 as filler in
formulations with both HPMC and HPC. [Projekat Ministarstva nauke Republike
Srbije, br. TR 34007] |
| first_indexed | 2024-12-13T18:27:30Z |
| format | Article |
| id | doaj.art-96a14791b7f64c198b9c2b44b13e6546 |
| institution | Directory Open Access Journal |
| issn | 1451-9372 2217-7434 |
| language | English |
| last_indexed | 2024-12-13T18:27:30Z |
| publishDate | 2015-01-01 |
| publisher | Association of the Chemical Engineers of Serbia |
| record_format | Article |
| series | Chemical Industry and Chemical Engineering Quarterly |
| spelling | doaj.art-96a14791b7f64c198b9c2b44b13e65462022-12-21T23:35:34ZengAssociation of the Chemical Engineers of SerbiaChemical Industry and Chemical Engineering Quarterly1451-93722217-74342015-01-0121336937810.2298/CICEQ140613040N1451-93721400040NComparison of drug release and mechanical properties of tramadol-hydrochloride matrix tablets prepared with selected hydrophilic polymersNikolić Nenad D.0Medarević Đorđe P.1Đuriš Jelena D.2Vasiljević Dragana D.3Hemofarm a.d., VršacFaculty of Pharmacy, Department of Pharmaceutical Technology, BelgradeFaculty of Pharmacy, Department of Pharmaceutical Technology, BelgradeFaculty of Pharmacy, Department of Pharmaceutical Technology, BelgradeThis study investigates using of high molecular weight hydrophilic polymers, hypromellose and hydroxypropylcellulose, for the preparation of sustained release matrix tablets containing high dose, highly soluble drug, tramadol HCl. Proportion of polymer, type of insoluble filler, proportion of tramadol HCl, amount of drug in the tablet and compression pressure were recognized as critical formulation and process parameters and their influence on drug release and tablet mechanical properties was evaluated. Tensile strength was used as indicator of mechanical properties of the tablets. Experiments were performed with utilization of compaction simulator as a device which simulates compaction profiles of large scale rotary tablet presses. In formulations with both polymers proportion of tramadol HCl was the most critical formulation parameter wherein increasing of the tramadol HCl proportion increased its release rate in early stages of drug release. Regarding the tablet mechanical characteristics, the influence of the filler type has the most pronounced effect in formulations with both polymers. Higher tensile strengths were obtained with Avicel PH 102 as filler in formulations with both HPMC and HPC. [Projekat Ministarstva nauke Republike Srbije, br. TR 34007]http://www.doiserbia.nb.rs/img/doi/1451-9372/2015/1451-93721400040N.pdftramadol HClmatrix tabletshypromellosehydroxypropylcellulosedrug releasetensile strength |
| spellingShingle | Nikolić Nenad D. Medarević Đorđe P. Đuriš Jelena D. Vasiljević Dragana D. Comparison of drug release and mechanical properties of tramadol-hydrochloride matrix tablets prepared with selected hydrophilic polymers Chemical Industry and Chemical Engineering Quarterly tramadol HCl matrix tablets hypromellose hydroxypropylcellulose drug release tensile strength |
| title | Comparison of drug release and mechanical properties of tramadol-hydrochloride matrix tablets prepared with selected hydrophilic polymers |
| title_full | Comparison of drug release and mechanical properties of tramadol-hydrochloride matrix tablets prepared with selected hydrophilic polymers |
| title_fullStr | Comparison of drug release and mechanical properties of tramadol-hydrochloride matrix tablets prepared with selected hydrophilic polymers |
| title_full_unstemmed | Comparison of drug release and mechanical properties of tramadol-hydrochloride matrix tablets prepared with selected hydrophilic polymers |
| title_short | Comparison of drug release and mechanical properties of tramadol-hydrochloride matrix tablets prepared with selected hydrophilic polymers |
| title_sort | comparison of drug release and mechanical properties of tramadol hydrochloride matrix tablets prepared with selected hydrophilic polymers |
| topic | tramadol HCl matrix tablets hypromellose hydroxypropylcellulose drug release tensile strength |
| url | http://www.doiserbia.nb.rs/img/doi/1451-9372/2015/1451-93721400040N.pdf |
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