<i>Bacteroides fragilis</i> Toxin Induces Intestinal Epithelial Cell Secretion of Interleukin-8 by the E-Cadherin/β-Catenin/NF-κB Dependent Pathway

<i>Bacteroides fragilis</i> Toxin Induces Intestinal Epithelial Cell Secretion of Interleukin-8 by the E-Cadherin/β-Catenin/NF-κB Dependent Pathway

Enterotoxigenic <i>Bacteroides fragilis</i> (ETBF) has emerged as a gut microbiome pathogen that can promote colitis associated cancer in humans. ETBF secretes the metalloprotease, <i>B. fragilis</i> toxin (BFT), which can induce ectodomain cleavage of E-cadherin and IL-8 sec...

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Bibliographic Details
Main Authors: Chang-Gun Lee, Soonjae Hwang, Sun-Yeong Gwon, Chanoh Park, Minjeong Jo, Ju-Eun Hong, Ki-Jong Rhee
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Biomedicines
Subjects:
enterotoxigenic <i>Bacteroides fragilis</i>
colonic epithelial cell
E-cadherin
β-catenin
NF-κB
Online Access:https://www.mdpi.com/2227-9059/10/4/827

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https://www.mdpi.com/2227-9059/10/4/827

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