A direct regulatory link between microRNA-137 and SHANK2: implications for neuropsychiatric disorders

A direct regulatory link between microRNA-137 and SHANK2: implications for neuropsychiatric disorders

Abstract Background Mutations in the SHANK genes, which encode postsynaptic scaffolding proteins, have been linked to a spectrum of neurodevelopmental disorders. The SHANK genes and the schizophrenia-associated microRNA-137 show convergence on several levels, as they are both expressed at the synaps...

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Bibliographic Details
Main Authors: Ana de Sena Cortabitarte, Simone Berkel, Flavia-Bianca Cristian, Christine Fischer, Gudrun A. Rappold
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Neurodevelopmental Disorders
Subjects:
SHANK2
microRNA
miR-137
Schizophrenia
Autism
Intellectual disability
Online Access:http://link.springer.com/article/10.1186/s11689-018-9233-1

Internet

http://link.springer.com/article/10.1186/s11689-018-9233-1

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