CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB Pathway

CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB Pathway

Age-related macular degeneration (AMD), the leading cause of vision loss in the elderly, is a degenerative disease of the macula, where retinal pigment epithelium (RPE) cells are damaged in the early stages of the disease, and chronic inflammatory processes may be involved. Besides aging and lifesty...

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Bibliographic Details
Main Authors: Angela Armento, Tiziana L. Schmidt, Inga Sonntag, David A. Merle, Mohamed Ali Jarboui, Ellen Kilger, Simon J. Clark, Marius Ueffing
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
age-related macular degeneration (AMD)
retinal pigment epithelium (RPE) cells
complement factor H (CFH)
inflammation
cytokines
NF-κB pathway
Online Access:https://www.mdpi.com/1422-0067/22/16/8727

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https://www.mdpi.com/1422-0067/22/16/8727

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