Sec-O-Glucosylhamaudol Inhibits RANKL-Induced Osteoclastogenesis by Repressing 5-LO and AKT/GSK3β Signaling

Sec-O-Glucosylhamaudol Inhibits RANKL-Induced Osteoclastogenesis by Repressing 5-LO and AKT/GSK3β Signaling

Sec-O-glucosylhamaudol (SOG), an active flavonoid compound derived from the root of Saposhnikovia divaricata (Turcz. ex Ledeb.) Schischk., exhibits analgesic, anti-inflammatory, and high 5-lipoxygenase (5-LO) inhibitory effects. However, its effect on osteoclastogenesis was unclear. We demonstrated...

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Bibliographic Details
Main Authors: Jinjin Cao, Ming-Xue Zhou, Xinyan Chen, Menglu Sun, Congmin Wei, Qisheng Peng, Zhou Cheng, Wanchun Sun, Hongbing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
Sec-O-glucosylhamaudol
osteoclasts
NFATc1
GSK3β
5-lipoxygenase
AKT
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.880988/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.880988/full

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