TOP2A deficiency leads to human recurrent spontaneous abortion and growth retardation of mouse pre-implantation embryos

TOP2A deficiency leads to human recurrent spontaneous abortion and growth retardation of mouse pre-implantation embryos

Abstract Background Recurrent spontaneous abortion (RSA), is a dangerous pregnancy-related condition and is a subject of debate in the gynaecology and obstetrics communities. The objective of this study was to determine the function of DNA Topoisomerase II Alpha (TOP2A) in RSA and elucidate the unde...

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Bibliographic Details
Main Authors: Yuhan Duan, Huijia Fu, Jiayu Huang, Nanlin Yin, Linhong Liu, Xiru Liu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Molecular Medicine
Subjects:
TOP2A
Proliferation
Apoptosis
Cell cycle
Migration
Invasion
Online Access:https://doi.org/10.1186/s10020-022-00592-4

Internet

https://doi.org/10.1186/s10020-022-00592-4

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