Non-Targeted Metabolomics Investigation of a Sub-Chronic Variable Stress Model Unveils Sex-Dependent Metabolic Differences Induced by Stress

Non-Targeted Metabolomics Investigation of a Sub-Chronic Variable Stress Model Unveils Sex-Dependent Metabolic Differences Induced by Stress

Depression is twice as prevalent in women as in men, however, most preclinical studies of depression have used male rodent models. This study aimed to examine how stress affects metabolic profiles depending on sex using a rodent depression model: sub-chronic variable stress (SCVS). The SCVS model of...

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Bibliographic Details
Main Authors: Seulgi Kang, Woonhee Kim, Jimin Nam, Ke Li, Yua Kang, Boyeon Bae, Kwang-Hoon Chun, ChiHye Chung, Jeongmi Lee
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
sex-dependent depression
metabolomics
rodent stress model
energy metabolism
hypothalamic-pituitary-adrenal axis
Online Access:https://www.mdpi.com/1422-0067/25/4/2443

Internet

https://www.mdpi.com/1422-0067/25/4/2443

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