Necdin shapes serotonergic development and SERT activity modulating breathing in a mouse model for Prader-Willi syndrome

Necdin shapes serotonergic development and SERT activity modulating breathing in a mouse model for Prader-Willi syndrome

Prader-Willi syndrome (PWS) is a genetic neurodevelopmental disorder that presents with hypotonia and respiratory distress in neonates. The Necdin-deficient mouse is the only model that reproduces the respiratory phenotype of PWS (central apnea and blunted response to respiratory challenges). Here,...

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Bibliographic Details
Main Authors: Valéry Matarazzo, Laura Caccialupi, Fabienne Schaller, Yuri Shvarev, Nazim Kourdougli, Alessandra Bertoni, Clément Menuet, Nicolas Voituron, Evan Deneris, Patricia Gaspar, Laurent Bezin, Pascale Durbec, Gérard Hilaire, Françoise Muscatelli
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-10-01
Series:eLife
Subjects:
serotonin
necdin
Prader-Willi Syndrome
respiration
apnea
neurodevelopment
Online Access:https://elifesciences.org/articles/32640

Internet

https://elifesciences.org/articles/32640

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