Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells

Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells

The global health burden due to sepsis and the associated cytokine storm is substantial. While early intervention has improved survival during the cytokine storm, those that survive can enter a state of chronic immunoparalysis defined by transient lymphopenia and functional deficits of surviving cel...

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Bibliographic Details
Main Authors: Isaac J Jensen, Xiang Li, Patrick W McGonagill, Qiang Shan, Micaela G Fosdick, Mikaela M Tremblay, Jon CD Houtman, Hai-Hui Xue, Thomas S Griffith, Weiqun Peng, Vladimir P Badovinac
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-10-01
Series:eLife
Subjects:
CD8 T cell
central memory
homeostatic proliferation
sepsis
Online Access:https://elifesciences.org/articles/70989

Internet

https://elifesciences.org/articles/70989

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