Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated osteomyelitis

Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated osteomyelitis

Abstract Eradication of MRSA osteomyelitis requires elimination of distinct biofilms. To overcome this, we developed bisphosphonate-conjugated sitafloxacin (BCS, BV600072) and hydroxybisphosphonate-conjugate sitafloxacin (HBCS, BV63072), which achieve “target-and-release” drug delivery proximal to t...

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Bibliographic Details
Main Authors: Youliang Ren, Jason Weeks, Thomas Xue, Joshua Rainbolt, Karen L. de Mesy Bentley, Ye Shu, Yuting Liu, Elysia Masters, Philip Cherian, Charles E. McKenna, Jeffrey Neighbors, Frank H. Ebetino, Edward M. Schwarz, Shuting Sun, Chao Xie
Format: Article
Language:English
Published: Nature Publishing Group 2023-10-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-023-00287-4

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https://doi.org/10.1038/s41413-023-00287-4

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