ERK signaling controls productive HIF‐1 binding to chromatin and cancer cell adaptation to hypoxia through HIF‐1α interaction with NPM1

ERK signaling controls productive HIF‐1 binding to chromatin and cancer cell adaptation to hypoxia through HIF‐1α interaction with NPM1

The hypoxia‐inducible factor HIF‐1 is essential for oxygen homeostasis. Despite its well‐understood oxygen‐dependent expression, regulation of its transcriptional activity remains unclear. We show that phosphorylation by extracellular signal‐regulated kinases1/2 (ERK1/2), in addition to promoting HI...

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Bibliographic Details
Main Authors: Kreon Koukoulas, Antonis Giakountis, Angeliki Karagiota, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis
Format: Article
Language:English
Published: Wiley 2021-12-01
Series:Molecular Oncology
Subjects:
cancer
HIF
hypoxia
NPM1
nucleophosmin
Online Access:https://doi.org/10.1002/1878-0261.13080

Internet

https://doi.org/10.1002/1878-0261.13080

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