Exosome-sheathed ROS-responsive nanogel to improve targeted therapy in perimenopausal depression
Abstract The development of natural membranes as coatings for nanoparticles to traverse the blood-brain barrier (BBB) presents an effective approach for treating central nervous system (CNS) disorders. In this study, we have designed a nanogel loaded with PACAP and estrogen (E2), sheathed with exoso...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-023-02005-y |
| _version_ | 1797556732680994816 |
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| author | Yue Hu Min Zhao Hui Wang Yang Guo Xiaolan Cheng Tong Zhao Hanqing Wang Yafeng Zhang Yong Ma Weiwei Tao |
| author_facet | Yue Hu Min Zhao Hui Wang Yang Guo Xiaolan Cheng Tong Zhao Hanqing Wang Yafeng Zhang Yong Ma Weiwei Tao |
| author_sort | Yue Hu |
| collection | DOAJ |
| description | Abstract The development of natural membranes as coatings for nanoparticles to traverse the blood-brain barrier (BBB) presents an effective approach for treating central nervous system (CNS) disorders. In this study, we have designed a nanogel loaded with PACAP and estrogen (E2), sheathed with exosomes and responsive to reactive oxygen species (ROS), denoted as HA NGs@exosomes. The objective of this novel design is to serve as a potent drug carrier for the targeted treatment of perimenopausal depression. The efficient cellular uptake and BBB penetration of HA NGs@exosomes has been demonstrated in vitro and in vivo. Following intranasal intervention with HA NGs@exosomes, ovariectomized mice under chronic unpredictable mild stress (CUMS) have shown improved behavioral performance, indicating that HA NGs@exosomes produced a rapid-onset antidepressant effect. Moreover, HA NGs@exosomes exhibit notable antioxidant and anti-inflammatory properties and may regulate the expression of pivotal proteins in the PACAP/PAC1 pathway to promote synaptic plasticity. Our results serve as a proof-of-concept for the utility of exosome-sheathed ROS-responsive nanogel as a promising drug carrier for the treatment of perimenopausal depression. Graphical Abstract |
| first_indexed | 2024-03-10T17:07:03Z |
| format | Article |
| id | doaj.art-96b637f015234557964ef04c113b7724 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-03-10T17:07:03Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-96b637f015234557964ef04c113b77242023-11-20T10:47:57ZengBMCJournal of Nanobiotechnology1477-31552023-08-0121112210.1186/s12951-023-02005-yExosome-sheathed ROS-responsive nanogel to improve targeted therapy in perimenopausal depressionYue Hu0Min Zhao1Hui Wang2Yang Guo3Xiaolan Cheng4Tong Zhao5Hanqing Wang6Yafeng Zhang7Yong Ma8Weiwei Tao9Jiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease, Wuxi TCM Hospital Affiliated to Nanjing University of Chinese MedicineJiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease, Wuxi TCM Hospital Affiliated to Nanjing University of Chinese MedicineSchool of pharmacology, Nanjing University of Chinese MedicineJiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease, Wuxi TCM Hospital Affiliated to Nanjing University of Chinese MedicineJiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease, Wuxi TCM Hospital Affiliated to Nanjing University of Chinese MedicineJiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease, Wuxi TCM Hospital Affiliated to Nanjing University of Chinese MedicineSchool of pharmacology, Ningxia Medical UniversityJiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease, Wuxi TCM Hospital Affiliated to Nanjing University of Chinese MedicineJiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease, Wuxi TCM Hospital Affiliated to Nanjing University of Chinese MedicineJiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease, Wuxi TCM Hospital Affiliated to Nanjing University of Chinese MedicineAbstract The development of natural membranes as coatings for nanoparticles to traverse the blood-brain barrier (BBB) presents an effective approach for treating central nervous system (CNS) disorders. In this study, we have designed a nanogel loaded with PACAP and estrogen (E2), sheathed with exosomes and responsive to reactive oxygen species (ROS), denoted as HA NGs@exosomes. The objective of this novel design is to serve as a potent drug carrier for the targeted treatment of perimenopausal depression. The efficient cellular uptake and BBB penetration of HA NGs@exosomes has been demonstrated in vitro and in vivo. Following intranasal intervention with HA NGs@exosomes, ovariectomized mice under chronic unpredictable mild stress (CUMS) have shown improved behavioral performance, indicating that HA NGs@exosomes produced a rapid-onset antidepressant effect. Moreover, HA NGs@exosomes exhibit notable antioxidant and anti-inflammatory properties and may regulate the expression of pivotal proteins in the PACAP/PAC1 pathway to promote synaptic plasticity. Our results serve as a proof-of-concept for the utility of exosome-sheathed ROS-responsive nanogel as a promising drug carrier for the treatment of perimenopausal depression. Graphical Abstracthttps://doi.org/10.1186/s12951-023-02005-yExosomeNanogelPerimenopausal DepressionPACAPEstrogen |
| spellingShingle | Yue Hu Min Zhao Hui Wang Yang Guo Xiaolan Cheng Tong Zhao Hanqing Wang Yafeng Zhang Yong Ma Weiwei Tao Exosome-sheathed ROS-responsive nanogel to improve targeted therapy in perimenopausal depression Journal of Nanobiotechnology Exosome Nanogel Perimenopausal Depression PACAP Estrogen |
| title | Exosome-sheathed ROS-responsive nanogel to improve targeted therapy in perimenopausal depression |
| title_full | Exosome-sheathed ROS-responsive nanogel to improve targeted therapy in perimenopausal depression |
| title_fullStr | Exosome-sheathed ROS-responsive nanogel to improve targeted therapy in perimenopausal depression |
| title_full_unstemmed | Exosome-sheathed ROS-responsive nanogel to improve targeted therapy in perimenopausal depression |
| title_short | Exosome-sheathed ROS-responsive nanogel to improve targeted therapy in perimenopausal depression |
| title_sort | exosome sheathed ros responsive nanogel to improve targeted therapy in perimenopausal depression |
| topic | Exosome Nanogel Perimenopausal Depression PACAP Estrogen |
| url | https://doi.org/10.1186/s12951-023-02005-y |
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