The Human TET2 Gene Contains Three Distinct Promoter Regions With Differing Tissue and Developmental Specificities

The Human TET2 Gene Contains Three Distinct Promoter Regions With Differing Tissue and Developmental Specificities

Tet methylcytosine dioxygenase 2 (TET2) is a tumor suppressor gene that is inactivated in a wide range of hematological cancers. TET2 enzymatic activity converts 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC), an essential step in DNA demethylation. Human TET2 is highly expressed in pl...

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Bibliographic Details
Main Authors: Hong Lou, Hongchuan Li, Kevin J. Ho, Luke L. Cai, Andy S. Huang, Tyler R. Shank, Michael R. Verneris, Michael L. Nickerson, Michael Dean, Stephen K. Anderson
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
human
TET2
alternative promoters
demethylation
differentiation
mRNA isoforms
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00099/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00099/full

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