Targeting MUC1-C Suppresses Chronic Activation of Cytosolic Nucleotide Receptors and STING in Triple-Negative Breast Cancer

Targeting MUC1-C Suppresses Chronic Activation of Cytosolic Nucleotide Receptors and STING in Triple-Negative Breast Cancer

The MUC1-C apical transmembrane protein is activated in the acute response of epithelial cells to inflammation. However, chronic MUC1-C activation promotes cancer progression, emphasizing the importance of MUC1-C as a target for treatment. We report here that MUC1-C is necessary for intrinsic expres...

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Bibliographic Details
Main Authors: Nami Yamashita, Atsushi Fushimi, Yoshihiro Morimoto, Atrayee Bhattacharya, Masayuki Hagiwara, Masaaki Yamamoto, Tsuyoshi Hata, Geoffrey I. Shapiro, Mark D. Long, Song Liu, Donald Kufe
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
MUC1-C
TNBC
cGAS
STING
ISG15
Online Access:https://www.mdpi.com/2072-6694/14/11/2580

Internet

https://www.mdpi.com/2072-6694/14/11/2580

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