Multimodal imaging study of the 5-HT1A receptor biased agonist, NLX-112, in a model of L-DOPA-induced dyskinesia

Multimodal imaging study of the 5-HT1A receptor biased agonist, NLX-112, in a model of L-DOPA-induced dyskinesia

Introduction: The leading treatment for motor signs of Parkinson's disease is L-DOPA, but, upon extended use, it can lead to levodopa-induced dyskinesia (LID). Serotonergic neurons are involved in LID etiology and previous pre-clinical studies have shown that NLX-112, a 5-HT1A biased agonist, h...

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Bibliographic Details
Main Authors: Sarah Chaib, Benjamin Vidal, Caroline Bouillot, Ronan Depoortere, Adrian Newman-Tancredi, Luc Zimmer, Elise Levigoureux
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:NeuroImage: Clinical
Subjects:
FDG
fMRI
Serotonin
Levodopa-induced dyskinesia
Biased agonist
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158223001882

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http://www.sciencedirect.com/science/article/pii/S2213158223001882

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