Conventional DNA-Damaging Cancer Therapies and Emerging cGAS-STING Activation: A Review and Perspectives Regarding Immunotherapeutic Potential

Conventional DNA-Damaging Cancer Therapies and Emerging cGAS-STING Activation: A Review and Perspectives Regarding Immunotherapeutic Potential

Many traditional cancer treatments such as radiation and chemotherapy are known to induce cellular DNA damage as part of their cytotoxic activity. The cGAS-STING signaling axis, a key member of the DNA damage response that acts as a sensor of foreign or aberrant cytosolic DNA, is helping to rational...

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Bibliographic Details
Main Authors: Jordan D. Lewicky, Alexandrine L. Martel, Mukul Raj Gupta, René Roy, Galaxia M. Rodriguez, Barbara C. Vanderhyden, Hoang-Thanh Le
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cancers
Subjects:
DNA damage response
cGAS-STING
cancer immunotherapy
chemotherapy
radiation
tumor microenvironment
Online Access:https://www.mdpi.com/2072-6694/15/16/4127

Internet

https://www.mdpi.com/2072-6694/15/16/4127

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