Effects of In Vitro Fermentation of Polysialic Acid and Sialic Acid on Gut Microbial Community Composition and Metabolites in Healthy Humans
The influence of polysialic acid (PSA) and sialic acid (SA) on the gut microbial community composition and metabolites in healthy humans was investigated using a bionic gastrointestinal reactor. The results indicated that PSA and SA significantly changed the gut microbiota and metabolites to differe...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/13/3/481 |
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| author | Zhongwei Yin Li Zhu Minjie Gao Dan Yu Zijian Zhang Ling Zhu Xiaobei Zhan |
| author_facet | Zhongwei Yin Li Zhu Minjie Gao Dan Yu Zijian Zhang Ling Zhu Xiaobei Zhan |
| author_sort | Zhongwei Yin |
| collection | DOAJ |
| description | The influence of polysialic acid (PSA) and sialic acid (SA) on the gut microbial community composition and metabolites in healthy humans was investigated using a bionic gastrointestinal reactor. The results indicated that PSA and SA significantly changed the gut microbiota and metabolites to different degrees. PSA can increase the relative abundances of <i>Faecalibacterium</i> and <i>Allisonella</i>, whereas SA can increase those of <i>Bifidobacterium</i> and <i>Megamonas</i>. Both can significantly increase the content of short-chain fatty acids. The results of metabolome analysis showed that PSA can upregulate ergosterol peroxide and gallic acid and downregulate the harmful metabolite N-acetylputrescine. SA can upregulate 4-pyridoxic acid and lipoic acid. PSA and SA affect gut microbiota and metabolites in different ways and have positive effects on human health. These results will provide a reference for the further development of PSA- and SA-related functional foods and health products. |
| first_indexed | 2024-03-08T03:56:51Z |
| format | Article |
| id | doaj.art-96c6ead38be0438c9ec5164f27021733 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-08T03:56:51Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-96c6ead38be0438c9ec5164f270217332024-02-09T15:12:20ZengMDPI AGFoods2304-81582024-02-0113348110.3390/foods13030481Effects of In Vitro Fermentation of Polysialic Acid and Sialic Acid on Gut Microbial Community Composition and Metabolites in Healthy HumansZhongwei Yin0Li Zhu1Minjie Gao2Dan Yu3Zijian Zhang4Ling Zhu5Xiaobei Zhan6Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaThe influence of polysialic acid (PSA) and sialic acid (SA) on the gut microbial community composition and metabolites in healthy humans was investigated using a bionic gastrointestinal reactor. The results indicated that PSA and SA significantly changed the gut microbiota and metabolites to different degrees. PSA can increase the relative abundances of <i>Faecalibacterium</i> and <i>Allisonella</i>, whereas SA can increase those of <i>Bifidobacterium</i> and <i>Megamonas</i>. Both can significantly increase the content of short-chain fatty acids. The results of metabolome analysis showed that PSA can upregulate ergosterol peroxide and gallic acid and downregulate the harmful metabolite N-acetylputrescine. SA can upregulate 4-pyridoxic acid and lipoic acid. PSA and SA affect gut microbiota and metabolites in different ways and have positive effects on human health. These results will provide a reference for the further development of PSA- and SA-related functional foods and health products.https://www.mdpi.com/2304-8158/13/3/481prebioticsin vitro digestionfecal fermentationintestinal microorganismshort-chain fatty aciddifferential metabolites |
| spellingShingle | Zhongwei Yin Li Zhu Minjie Gao Dan Yu Zijian Zhang Ling Zhu Xiaobei Zhan Effects of In Vitro Fermentation of Polysialic Acid and Sialic Acid on Gut Microbial Community Composition and Metabolites in Healthy Humans Foods prebiotics in vitro digestion fecal fermentation intestinal microorganism short-chain fatty acid differential metabolites |
| title | Effects of In Vitro Fermentation of Polysialic Acid and Sialic Acid on Gut Microbial Community Composition and Metabolites in Healthy Humans |
| title_full | Effects of In Vitro Fermentation of Polysialic Acid and Sialic Acid on Gut Microbial Community Composition and Metabolites in Healthy Humans |
| title_fullStr | Effects of In Vitro Fermentation of Polysialic Acid and Sialic Acid on Gut Microbial Community Composition and Metabolites in Healthy Humans |
| title_full_unstemmed | Effects of In Vitro Fermentation of Polysialic Acid and Sialic Acid on Gut Microbial Community Composition and Metabolites in Healthy Humans |
| title_short | Effects of In Vitro Fermentation of Polysialic Acid and Sialic Acid on Gut Microbial Community Composition and Metabolites in Healthy Humans |
| title_sort | effects of in vitro fermentation of polysialic acid and sialic acid on gut microbial community composition and metabolites in healthy humans |
| topic | prebiotics in vitro digestion fecal fermentation intestinal microorganism short-chain fatty acid differential metabolites |
| url | https://www.mdpi.com/2304-8158/13/3/481 |
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