Single-cell transcriptome mapping identifies a local, innate B cell population driving chronic rejection after lung transplantation

Single-cell transcriptome mapping identifies a local, innate B cell population driving chronic rejection after lung transplantation

Bronchiolitis obliterans syndrome (BOS) is the main reason for poor outcomes after lung transplantation (LTx). We and others have recently identified B cells as major contributors to BOS after LTx. The extent of B cell heterogeneity and the relative contributions of B cell subpopulations to BOS, how...

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Bibliographic Details
Main Authors: Natalia F. Smirnova, Kent Riemondy, Marta Bueno, Susan Collins, Pavan Suresh, Xingan Wang, Kapil N. Patel, Carlyne Cool, Melanie Königshoff, Nirmal S. Sharma, Oliver Eickelberg
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-09-01
Series:JCI Insight
Subjects:
Pulmonology
Transplantation
Online Access:https://doi.org/10.1172/jci.insight.156648

Internet

https://doi.org/10.1172/jci.insight.156648

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