Novel psoralen derivatives as anti-breast cancer agents and their light-activated cytotoxicity against HER2 positive breast cancer cells

Abstract Psoralen derivatives are well known for their unique phototoxicity and also exhibits promising anti-breast cancer activity both in the presence and the absence of UVA irradiation. However, the structure–activity relationship on this scaffold remains lacking. Herein, a series of psoralen der...

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Bibliographic Details
Main Authors: Chiphada Aekrungrueangkit, Sirilak Wangngae, Anyanee Kamkaew, Ruchuta Ardkhean, Sanit Thongnest, Jutatip Boonsombat, Somsak Ruchirawat, Tanatorn Khotavivattana
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-17625-x