Screening and molecular dynamics simulation of compounds inhibiting MurB enzyme of drug-resistant Mycobacterium tuberculosis: An in-silico approach

Screening and molecular dynamics simulation of compounds inhibiting MurB enzyme of drug-resistant Mycobacterium tuberculosis: An in-silico approach

Mycobacterium tuberculosis (MTB) is becoming more and more resistant to drugs and it is a common problem, making current antimicrobials ineffective and highlighting the need for new TB drugs. One of the promising targets for treating MTB is MurB enzymes. This study aimed to identify potential inhibi...

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Bibliographic Details
Main Authors: Ankit Verma, Vijay Kumar, Bindu Naik, Javed Masood Khan, Pallavi Singh, Per Erik Joakim Saris, Sanjay Gupta
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Saudi Journal of Biological Sciences
Subjects:
Drug resistance
M. tuberculosis
Peptidoglycan
MurB
Docking
MD simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S1319562X23001754

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http://www.sciencedirect.com/science/article/pii/S1319562X23001754

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