Proteomics reveals unique identities of human TGF-β-induced and thymus-derived CD4+ regulatory T cells

Abstract The CD4+ regulatory T (Treg) cell lineage, defined by FOXP3 expression, comprises thymus-derived (t)Treg cells and peripherally induced (p)Treg cells. As a model for Treg cells, studies employ TGF-β-induced (i)Treg cells generated from CD4+ conventional T (Tconv) cells in vitro. Here, we de...

Full description

Bibliographic Details
Main Authors: Mark Mensink, Ellen Schrama, Eloy Cuadrado, Derk Amsen, Sander de Kivit, Jannie Borst
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-23515-z