Aging is associated with an insufficient early inflammatory response of lung endothelial cells in SARS-CoV-2 infection

Aging is associated with an insufficient early inflammatory response of lung endothelial cells in SARS-CoV-2 infection

Advanced age is associated with an increased susceptibility to Coronavirus Disease (COVID)-19 and more severe outcomes, although the underlying mechanisms are understudied. The lung endothelium is located next to infected epithelial cells and bystander inflammation may contribute to thromboinflammat...

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Bibliographic Details
Main Authors: Saravanan Subramaniam, Devin Kenney, Archana Jayaraman, Aoife Kateri O’Connell, Sarah Walachowski, Paige Montanaro, Christoph Reinhardt, Giuseppe Colucci, Nicholas A. Crossland, Florian Douam, Markus Bosmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Immunology
Subjects:
host-pathogen interaction
pattern recognition receptors
cytokines
inflammation
thromboinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1397990/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1397990/full

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