5,6-dimethylxanthenone-4-acetic acid (DMXAA), a partial STING agonist, competes for human STING activation

5,6-dimethylxanthenone-4-acetic acid (DMXAA), a partial STING agonist, competes for human STING activation

5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a mouse-selective stimulator of interferon gene (STING) agonist exerting STING-dependent anti-tumor activity. Although DMXAA cannot fully activate human STING, DMXAA reached phase III in lung cancer clinical trials. How DMXAA is effective against human...

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Bibliographic Details
Main Authors: Burcu Temizoz, Takayuki Shibahara, Kou Hioki, Tomoya Hayashi, Kouji Kobiyama, Michelle Sue Jann Lee, Naz Surucu, Erdal Sag, Atsushi Kumanogoh, Masahiro Yamamoto, Mayda Gursel, Seza Ozen, Etsushi Kuroda, Cevayir Coban, Ken J. Ishii
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
STING
partial agonist
DMXAA derivative
SAVI
HHMX
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1353336/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1353336/full

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