RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21

RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21

Abstract Background Prior evidence demonstrated that Regulator of G protein Signaling 6 (RGS6) translocates to the nucleolus in response to cytotoxic stress though the functional significance of this phenomenon remains unknown. Methods Utilizing in vivo gene manipulations in mice, primary murine car...

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Bibliographic Details
Main Authors: Abhishek Singh Sengar, Manish Kumar, Chetna Rai, Sreemoyee Chakraborti, Dinesh Kumar, Pranesh Kumar, Sukhes Mukherjee, Kausik Mondal, Adele Stewart, Biswanath Maity
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Translational Medicine
Subjects:
Cardiotoxicity
G-protein
RGS proteins
Chemotherapy
Nucleolar stress
Online Access:https://doi.org/10.1186/s12967-024-04985-3

Internet

https://doi.org/10.1186/s12967-024-04985-3

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