Molecular and Cellular Responses to Ionization Radiation in Untransformed Fibroblasts from the Rothmund–Thomson Syndrome: Influence of the Nucleo-Shuttling of the ATM Protein Kinase

Molecular and Cellular Responses to Ionization Radiation in Untransformed Fibroblasts from the Rothmund–Thomson Syndrome: Influence of the Nucleo-Shuttling of the ATM Protein Kinase

The Rothmund–Thomson syndrome (RTS) is a rare autosomal recessive disease associated with poikiloderma, telangiectasias, sun-sensitive rash, hair growth problems, juvenile cataracts and, for a subset of some RTS patients, a high risk of cancer, especially osteosarcoma. Most of the RTS cases are caus...

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Bibliographic Details
Main Authors: Joëlle Al-Choboq, Myriam Nehal, Laurène Sonzogni, Adeline Granzotto, Laura El Nachef, Juliette Restier-Verlet, Mira Maalouf, Elise Berthel, Bernard Aral, Nadège Corradini, Michel Bourguignon, Nicolas Foray
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Radiation
Subjects:
Rothmund–Thomson syndrome
radiosensitivity
DNA double-strand breaks
ATM
ionizing radiation
Online Access:https://www.mdpi.com/2673-592X/3/1/2

Internet

https://www.mdpi.com/2673-592X/3/1/2

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