Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells

Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells

Abstract Brain iron dysregulation associated with aging is closely related to motor and cognitive impairments in neurodegenerative diseases. The regulation of iron traffic at the blood-brain barrier (BBB) is crucial to maintain brain iron homeostasis. However, the specific mechanism has not been cla...

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Bibliografski detalji
Glavni autori: Linhao You, Pan-Pan Yu, Tianyu Dong, Wenhuan Guo, Shiyang Chang, Bingjie Zheng, Yunzhe Ci, Fudi Wang, Peng Yu, Guofen Gao, Yan-Zhong Chang
Format: Članak
Jezik:English
Izdano: Nature Publishing Group 2022-08-01
Serija:Cell Death and Disease
Online pristup:https://doi.org/10.1038/s41419-022-05043-w

Internet

https://doi.org/10.1038/s41419-022-05043-w

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