Pitx3 deficiency promotes age-dependent alterations in striatal medium spiny neurons

Pitx3 deficiency promotes age-dependent alterations in striatal medium spiny neurons

BackgroundThe classical motor symptoms of Parkinson’s disease (PD) are tightly linked to the gradual loss of dopamine within the striatum. Concomitantly, medium spiny neurons (MSNs) also experience morphological changes, such as reduced dendritic complexity and spine density, which may be potentiall...

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Bibliographic Details
Main Authors: Xi Chen, Zhaofei Yang, Yaping Shao, Kunhyok Kim, Yuanyuan Wang, Ying Wang, Haifeng Wu, Xiaolan Xu, Weidong Le
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
medium spiny neurons
neuronal morphology
DNA methylation
aging
Parkinson’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.960479/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2022.960479/full

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