Consideration of transmembrane water exchange in pharmacokinetic model significantly improves the accuracy of DCE-MRI in estimating cellular density: A pilot study in glioblastoma multiforme

Consideration of transmembrane water exchange in pharmacokinetic model significantly improves the accuracy of DCE-MRI in estimating cellular density: A pilot study in glioblastoma multiforme

Transmembrane water exchange (TWE) including transcytolemmal water exchange and transvascular water exchange is involved in many in vivo measurements and makes different contributions to the measuring results. In this study, we focus on the potential influence of TWE on the cell density parameter, i...

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Bibliographic Details
Main Authors: Zhenfeng Pang, Zejun Wang, Bao Wang, Kaiyue Guo, Cheng Meng, Yingchao Liu, Xueqian Kong, Ruiliang Bai
Format: Article
Language:English
Published: KeAi Communications Co. Ltd. 2022-11-01
Series:Magnetic Resonance Letters
Subjects:
DCE-MRI
Cell density
Transcytolemmal water exchange
Finite difference simulation
Glioblastoma multiforme
Online Access:http://www.sciencedirect.com/science/article/pii/S2772516222000171

Internet

http://www.sciencedirect.com/science/article/pii/S2772516222000171

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