Targeting the cochlin/SFRP1/CaMKII axis in the ocular posterior pole prevents the progression of nonpathologic myopia

Abstract Myopia is a major public health issue. However, interventional modalities for nonpathologic myopia are limited due to its complicated pathogenesis and the lack of precise targets. Here, we show that in guinea pig form-deprived myopia (FDM) and lens-induced myopia (LIM) models, the early ini...

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Bibliographic Details
Main Authors: Chao Geng, Siyi Liu, Jindan Wang, Sennan Wang, Weiran Zhang, Hua Rong, Yunshan Cao, Shuqing Wang, Zhiqing Li, Yan Zhang
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05267-2