Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma

Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma

Abstract Acquired resistance to immunotherapy remains a critical yet incompletely understood biological mechanism. Here, using a mouse model of pancreatic ductal adenocarcinoma (PDAC) to study tumor relapse following immunotherapy-induced responses, we find that resistance is reproducibly associated...

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Bibliographic Details
Main Authors: Il-Kyu Kim, Mark S. Diamond, Salina Yuan, Samantha B. Kemp, Benjamin M. Kahn, Qinglan Li, Jeffrey H. Lin, Jinyang Li, Robert J. Norgard, Stacy K. Thomas, Maria Merolle, Takeshi Katsuda, John W. Tobias, Timour Baslan, Katerina Politi, Robert H. Vonderheide, Ben Z. Stanger
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46048-7

Internet

https://doi.org/10.1038/s41467-024-46048-7

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