Genistein sensitizes bladder cancer cells to HCPT treatment in vitro and in vivo via ATM/NF-κB/IKK pathway-induced apoptosis.

Genistein sensitizes bladder cancer cells to HCPT treatment in vitro and in vivo via ATM/NF-κB/IKK pathway-induced apoptosis.

Bladder cancer is the most common malignant urological disease in China. Hydroxycamptothecin (HCPT) is a DNA topoisomerase I inhibitor, which has been utilized in chemotherapy for bladder cancer for nearly 40 years. Previous research has demonstrated that the isoflavone, genistein, can sensitize mul...

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Bibliographic Details
Main Authors: Yong Wang, He Wang, Wei Zhang, Chen Shao, Peng Xu, Chang Hong Shi, Jian Guo Shi, Yu Mei Li, Qiang Fu, Wei Xue, Yong Hua Lei, Jing Yu Gao, Juan Ying Wang, Xiao Ping Gao, Jin Qing Li, Jian Lin Yuan, Yun Tao Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3554754?pdf=render

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http://europepmc.org/articles/PMC3554754?pdf=render

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