Downregulation of MicroRNA-455-3p Links to Proliferation and Drug Resistance of Pancreatic Cancer Cells via Targeting TAZ
Drug resistance is a major cause of treatment failure in pancreatic cancer. The limited evidence indicates the involvement of miR-455-3p in chemotherapy resistance of cancer. Here we observed by qPCR that miR-455-3p was significantly decreased in pancreatic cancer tissues and cell lines. We then con...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-03-01
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| Series: | Molecular Therapy: Nucleic Acids |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253117303001 |
| _version_ | 1830402719455641600 |
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| author | Ting Zhan Xiaodong Huang Xia Tian Xiaoli Chen Yu Ding Hesheng Luo Yadong Zhang |
| author_facet | Ting Zhan Xiaodong Huang Xia Tian Xiaoli Chen Yu Ding Hesheng Luo Yadong Zhang |
| author_sort | Ting Zhan |
| collection | DOAJ |
| description | Drug resistance is a major cause of treatment failure in pancreatic cancer. The limited evidence indicates the involvement of miR-455-3p in chemotherapy resistance of cancer. Here we observed by qPCR that miR-455-3p was significantly decreased in pancreatic cancer tissues and cell lines. We then confirmed that the inhibition of miR-455-3p increased cell proliferation and gemcitabine resistance of pancreatic cancer, whereas forced overexpression of miR-455-3p had the opposite effect. Furthermore, we demonstrated that TAZ, which is associated with drug resistance of pancreatic cancer, is a new direct downstream target of miR-455-3p. Our present study suggests that miR-455-3p contributes to cell proliferation and drug resistance in pancreatic cancer cells via targeting TAZ. |
| first_indexed | 2024-12-20T16:58:18Z |
| format | Article |
| id | doaj.art-96ea96120da442329546eba28003f54a |
| institution | Directory Open Access Journal |
| issn | 2162-2531 |
| language | English |
| last_indexed | 2024-12-20T16:58:18Z |
| publishDate | 2018-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Nucleic Acids |
| spelling | doaj.art-96ea96120da442329546eba28003f54a2022-12-21T19:32:40ZengElsevierMolecular Therapy: Nucleic Acids2162-25312018-03-011021522610.1016/j.omtn.2017.12.002Downregulation of MicroRNA-455-3p Links to Proliferation and Drug Resistance of Pancreatic Cancer Cells via Targeting TAZTing Zhan0Xiaodong Huang1Xia Tian2Xiaoli Chen3Yu Ding4Hesheng Luo5Yadong Zhang6Department of Gastroenterology, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan 430060, China; Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Gastroenterology, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Gastroenterology, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Gastroenterology, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan 430060, ChinaKey Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, ChinaDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaKey Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China; Corresponding author: Yadong Zhang, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory for Molecular Diagnosis of Hubei Province, 26 Shengli Street, Wuhan 430014, China.Drug resistance is a major cause of treatment failure in pancreatic cancer. The limited evidence indicates the involvement of miR-455-3p in chemotherapy resistance of cancer. Here we observed by qPCR that miR-455-3p was significantly decreased in pancreatic cancer tissues and cell lines. We then confirmed that the inhibition of miR-455-3p increased cell proliferation and gemcitabine resistance of pancreatic cancer, whereas forced overexpression of miR-455-3p had the opposite effect. Furthermore, we demonstrated that TAZ, which is associated with drug resistance of pancreatic cancer, is a new direct downstream target of miR-455-3p. Our present study suggests that miR-455-3p contributes to cell proliferation and drug resistance in pancreatic cancer cells via targeting TAZ.http://www.sciencedirect.com/science/article/pii/S2162253117303001miR-455-3pTAZdrug resistancegemcitabinepancreatic cancer |
| spellingShingle | Ting Zhan Xiaodong Huang Xia Tian Xiaoli Chen Yu Ding Hesheng Luo Yadong Zhang Downregulation of MicroRNA-455-3p Links to Proliferation and Drug Resistance of Pancreatic Cancer Cells via Targeting TAZ Molecular Therapy: Nucleic Acids miR-455-3p TAZ drug resistance gemcitabine pancreatic cancer |
| title | Downregulation of MicroRNA-455-3p Links to Proliferation and Drug Resistance of Pancreatic Cancer Cells via Targeting TAZ |
| title_full | Downregulation of MicroRNA-455-3p Links to Proliferation and Drug Resistance of Pancreatic Cancer Cells via Targeting TAZ |
| title_fullStr | Downregulation of MicroRNA-455-3p Links to Proliferation and Drug Resistance of Pancreatic Cancer Cells via Targeting TAZ |
| title_full_unstemmed | Downregulation of MicroRNA-455-3p Links to Proliferation and Drug Resistance of Pancreatic Cancer Cells via Targeting TAZ |
| title_short | Downregulation of MicroRNA-455-3p Links to Proliferation and Drug Resistance of Pancreatic Cancer Cells via Targeting TAZ |
| title_sort | downregulation of microrna 455 3p links to proliferation and drug resistance of pancreatic cancer cells via targeting taz |
| topic | miR-455-3p TAZ drug resistance gemcitabine pancreatic cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2162253117303001 |
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