MMP-9 inhibition promotes anti-tumor immunity through disruption of biochemical and physical barriers to T-cell trafficking to tumors.

MMP-9 inhibition promotes anti-tumor immunity through disruption of biochemical and physical barriers to T-cell trafficking to tumors.

Matrix metalloproteinase-9 (MMP-9), whose expression is frequently dysregulated in cancer, promotes tumor growth, invasion, and metastasis by multiple mechanisms, including extracellular matrix remodeling and growth-factor and cytokine activation. We developed a monoclonal antibody against murine MM...

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Bibliographic Details
Main Authors: Vladi Juric, Chris O'Sullivan, Erin Stefanutti, Maria Kovalenko, Andrew Greenstein, Vivian Barry-Hamilton, Igor Mikaelian, Jeremiah Degenhardt, Peng Yue, Victoria Smith, Amanda Mikels-Vigdal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0207255

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https://doi.org/10.1371/journal.pone.0207255

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